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Does metoclopramide work immediately? Metoclopramide also helps to strengthen the stomach muscle so food can move into the intestine faster. Reglan tablets and syrup start working 30 to 60 minutes after being taken. The effects last several hours. 4 times a day вЂ“ (when possible) Give it 30 minutes before meals and once at bedtime. Does Reglan make you gain weight? Metoclopramide and unintended weight gain. RESULTS: The initial treatment of delayed gastric emptying with metoclopramide did not result in a significant change in body weight. However, an increase in the dose resulted in a 20% increase in the patient's body weight over a 2-month period.
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