What does Congenital Adrenal Hyperplasia mean? Congenital adrenal hyperplasia, also called CAH, is a group of genetic disorders in which the two adrenal glands do not work properly. People with CAH lack one of the enzymes (proteins that cause chemical changes in the body), steroid 21-hydroxylase. What is adrenal gland hyperplasia? Congenital adrenal hyperplasia (CAH) is a group of inherited genetic disorders that affect the adrenal glands, a pair of walnut-sized organs above your kidneys. In many cases, CAH results in lack of cortisol and overproduction of androgen. Is congenital adrenal hyperplasia life threatening? It is a milder form of CAH and is not life threatening. The adrenal glands produce normal or nearly normal amounts of cortisol and aldosterone. But they also make too much androgen. In late childhood or adulthood, signs of excess male hormone appear. Can Cushings lead to Addison's? Addison's disease is marked by deficiencies of aldosterone and cortisol, hormones produced in the adrenal glands. Aldosterone deficiency impairs water and sodium retention, which may lead to dehydration and hypovolemic shock. Addison's disease most often stems from an autoimmune response related to infection or cancer. Can Addison disease be misdiagnosed? Misdiagnosis of Addison's disease in a patient with end-stage renal disease. The physical examination was completely normal except for muscle weakness, hyperpigmentation on labial mucosa and skin in a patient. The laboratory tests revealed anemia and hypoglycemia.
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